Anaplastic thyroid carcinoma diagnosed after treatment of lenvatinib for papillary thyroid carcinoma
نویسندگان
چکیده
منابع مشابه
PAPILLARY THYROID CARCINOMA IN MASHHAD
Thyroid cancer is the most common endocrine malignancy. This study surveys the pathologic characteristics of thyroid cancerin Mashhad and study of papillary carcinoma in more detail. In this retrospective study, 108 out of 197 cases of thyroid cancer were papillary in type (55%), with female to male ratio of 1.91 which is lower than current reports. The age at the time of diagnosis ranged ...
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BACKGROUND Lenvatinib has been approved by regulatory agencies in Japan, the United States, and the European Union for treatment of radioiodine-refractory differentiated thyroid cancer (RR-DTC). Thyroid cancer, however, is a clinically diverse disease that includes anaplastic thyroid cancer (ATC), the subtype associated with the highest lethality. Effective therapy for ATC is an unmet need. P...
متن کاملHobnail variant of papillary thyroid carcinoma: molecular profiling and comparison to classical papillary thyroid carcinoma, poorly differentiated thyroid carcinoma and anaplastic thyroid carcinoma
BACKGROUND As a rare but aggressive papillary thyroid carcinoma (PTC) variant, the genetic changes of hobnail variant of PTC (HVPTC) are still unclear. RESULTS The prevalence of HVPTC was 1.69% (18/1062) of all PTC diagnosed in our cohort. 73 samples from 55 patients (17 HVPTC, 26 CPTC, 7 PDTC and 5 ATC) were successfully analyzed using targeted NGS with an 18-gene panel. Thirty-seven mutatio...
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INTRODUCTION Differentiated thyroid carcinomas (DTC) have good prognoses after complete resection. Nevertheless, when DTC is associated with an aerodigestive invasion, curative surgery is difficult to perform. However, there is no established neoadjuvant therapy for advanced DTC. PRESENTATION OF CASE A 73-year-old man with thyroid papillary carcinoma was referred to our hospital. A computed t...
متن کاملMulticentric Papillary Thyroid Carcinoma: Stratification for Treatment
Tumor stage is the main prognosticator of differentiated thyroid carcinomas, but it needs further stratification for multicentric neoplasms (most frequently papillary thyroid carcinomas, PTC), which frequently present as foci smaller than 1cm and are considered by default as high-risk tumors. Not all cases of multicentric PTC should be considered of high risk and they should be stratified to av...
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ژورنال
عنوان ژورنال: Endocrinology, Diabetes & Metabolism Case Reports
سال: 2019
ISSN: 2052-0573
DOI: 10.1530/edm-19-0085